1.1. New Procedures and Features
Additional Features in minor Release 6.5.12
In earlier versions of UNISTAT’s Four-Parameter Logistic Model procedure, calculation of estimated potency from relative potency results was left to the user. The new Potency dialogue enables the user to enter assigned potency of the standard, assumed potency of each test preparation and pre-dilutions for all preparations including the standard. UNISTAT will then calculate the estimated potency as described in sections 10.0.2. Doses, Dilutions and Potency and 10.0.3. Potency Calculation Example.
An option is introduced to compute the assay validity tests and fiducial confidence limits of estimated potency according to European Pharmacopoeia (1997-2008). See section 10.5.2.3. EP (European Pharmacopoeia).
Additional Features in minor Release 6.5.06
A full-featured implementation of Four-Parameter Logistic Model following recommendations of United States Pharmacopoeia (2010). Among others, Full and Reduced models, plate effects, equivalence tests and outlier detection are supported (see 10.5. Four-Parameter Logistic Model).
Additional Features in minor Release 6.5.05
Dose-response plot and estimated effective dose table for Logit / Probit / Gompit procedure including ED50 and fiducial limits (see 188.8.131.52.3. Output Options for Dose-Response Models).
Additional Features in minor Release 6.5.04
Multiple confidence levels for trend lines (see 184.108.40.206.1. Line).
New seed entry dialogue for K-Means Cluster Analysis.
New procedures in Version 6.5
Additional Features in Version 6.5
220.127.116.11. Nonlinear Regression Output Options predictions
7.2.5. Logit / Probit / Gompit loglog link function, predictions, marginal effects, average effects
7.2.6. Logistic Regression ROC, AUC analysis
18.104.22.168. GLM Variable Selection orthogonal polynomial contrasts
7.4.3. Multiple Comparisons output options
10.3.2.3. Effective Dose (or Lethal Dose) Spearman-Karber method
10.4.2.3. Combined Potency USP according to US Pharmacopoeia (2009)